Dr. He is the Chief of the Division of HPB Surgery and John L. Cameron Professor at the Johns Hopkins University. He is a surgical oncologist specializing in treating cancers and diseases of the liver, gallbladder, biliary system, pancreas, and stomach. Dr. He is actively involved in clinical research to improve patient outcomes. His research focuses on personalized treatment through stratifying pancreatic tumors on their molecular features. He holds several patents for anti-cancer vascular targeting agents and has  published extensively in peer-reviewed journals and lectured internationally. He serves on several national committees, including the NCCN panel on neuroendocrine tumors. He is the editorial board member of several surgical journals, including Annals of Surgical Oncology and Journal of Gastrointestinal Surgery.